Endocrine Abstracts

Type 2 diabetes and insulin resistance are associated with a complex change of metabolism of plasma lipoproteins that conveys a substantial part of increased cardiovascular (CV) risk of the diabetics. While quantity of lipoprotein particles (lipid concentrations) remain close to normal, their quality (composition) changes markedly. Lipoprotein metabolism in type 2 diabetes differs from normal at three levels. First, the production of very low-density lipoproteins (VLDLs) in th...